The first match between Newcastle and Manchester United this season came at Old Trafford and saw the Red Devils lose, 2-0. Newcastle will be looking to complete their first league double over United since the 1930/31 season.
Manchester United team news
United welcomed back midfielder Kobbie Mainoo on Thursday in the Europa League after a lengthy spell on the sidelines. Mainoo came on as a substitute but was lively on the field. Ruben Amorim might prefer to use him as a substitute again, while he's still regaining full fitness in terms of playing time.
Another face that is probable to return to the squad is youngster Chido Obi-Martin. Chido played with the U-21 team in their triumph over Nottingham Forest but was not in the squad for the fixture on Friday against Reading. This could suggest that Amorim has pulled him to play for the senior side again. While Zirkzee is likely to get the starting role up top, Chido could feature as a substitute, as Rasmus Hojlund failed to impress once again.
United don't have the ability to rotate their squad, due to the lack of available players. Matthijs de Ligt and Toby Collyer are both expected to miss the match. Some fans have called for Andre Onana to be replaced in goal, but Amorim is unlikely to change his starting keeper.
Newcastle team news
Newcastle are set to be without manager Eddie Howe, as he is in the hospital with an illness. Coaches Jason Tindall and Graeme Jones will take charge of the Magpies in his place.
Newcastle are hopeful to welcome back Anthony Gordon, who has missed some time with a groin injury and suspension. The team will be eager to have striker Alexander Isak fit again, as he has been quite influential this season. Isak has 20 goals and five assists so far this campaign.
The Magpies will be without Joe Willock, Sven Botman, Lewis Hall, and Jamaal Lascelles, who all have yet to regain full fitness.
How to watch Newcastle vs Manchester United
For viewers in the U.S, the match will be live on USA or on NBC.com. U.K. viewers can watch from Sky Sports. The game kicks off at 11:30 EST or 16:30 BST.